3D bio-printer printed the ear through the skin of the mouse

Scientists created 3D bio-printer that can print polymer plates with live cells through various tissues, polymerize biocompatible matrix by using infrared light. The main advantage of this printer — noninvasive treatment: to print a plastic item, you need to enter in the appropriate place in the solution-preparation. At the heart of technology lie two-layer nanoinitiative — inner part absorbs infrared light and emits ultraviolet, and the outer layer under the action of ultraviolet light starts the polymerization. The authors of an article published in the journal Science Advances, managed to print under the skin of a living mouse structure in the shape of the ear and also to heal the closed wound using a patch with stem cells.

3D bio-printers to print three-dimensional structures made of biocompatible materials with living cells, so are tissues and organs for transplantation. This technology has great potential in reconstructive surgery, but its use is limited by the need for invasive work on the exposed tissues and injuries. To access the internal injuries need to damage the surrounding tissue, therefore the preferred neinvazivnyi methods; they need plastic surgery.

Non-invasive relatively the same results for bioprinting is possible with light curing, when the liquid material solidifies under the action of light. Ultraviolet and blue light used to print tissues and organs, but the emission in this range does not penetrate deep into the tissue. Alternative technology may be the polymerization under the action of infrared light — it passes through living tissue and is already used for the controlled release of drugs, 3D imaging and optogenetic.

Scientists from Belgium, China and the United States under the leadership of Malin GOU (Gou Maling) from Sichuan University invented 3D-bioprinting-based photopolymerization in the near-infrared range. Device system microthermal directs the laser beam through the skin and starts the polymerization of the monomer biosovmestimy ink at the desired point. Noninitiator reactions collected from two layers: the internal part of the particles absorbs infrared light and emits it in the ultraviolet range, and the outer layer comprises a photoinitiator which absorbs all the ultraviolet light and the polymerized monomers in the hydrogel.

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