What are split inversions
On the way to the barley pan genome24.11.2020
Three years after the characterization of the first barley genome, an international team led by scientists from the IPK has now come a considerable step closer to deciphering the so-called pan genome of barley. The results have now been published in the science magazine Nature. How the researchers proceeded, what the new findings mean for breeding and what challenges are still waiting for the researchers, explains Prof. Dr. Interview with Nils Stein, Head of the Genomics Working Group on Genetic Resources.
Prof. Dr. Nils Stein Photo: IPK / Andreas Bähring
- You are now one big step closer to decoding the barley pan genome. What exactly is the pan genome about?
The concept of the pan genome describes the phenomenon that, contrary to original assumptions from times before genome sequencing, different individuals of a species do not share exactly the same amount of genetic information. Rather, all individuals have a large common body of shared genetic information (genes), the so-called “core genome”. In addition, there is a "variable genome", in the composition of which individual representatives of a species can differ to a greater or lesser extent. This contains, for example, genes that have been selected by adapting to certain environmental conditions. Only the pan genome, which becomes visible by comparing the genomes of numerous plants, ultimately shows the complete genome information of a species as well as the existing genetic diversity that is characteristic of this species, in our case barley. Put simply, it is a matter of differentiating the genetic information into precise intersections and subsets.
- How can the pan genome be characterized in the case of barley? And why is decryption so important?
In order to describe the pan genome of barley, one needs complete genome sequences for genetically very diverse barley genotypes. We estimate that at least 50-100 complete genome sequences are required to describe the genetic information of the barley crop, including all variants, in an approximately comprehensive manner. This is very time-consuming when you consider that the complete decoding of the genome of a barley was considered impossible for a long time. This is due to the fact that the barley genome has an 80-90 percent share of sequence units of different lengths, some of which can be repeated hundreds or thousands of times. This posed almost insoluble problems for bioinformatics for a long time when putting together the sequence snippets obtained as part of a genome sequencing project. The first complete decoding of a barley genome was only possible in 2017. In order to understand the genetic information of the entire barley species, it is now necessary to decipher the pan genome.
- How did you proceed exactly?
- What criteria was used for the selection?
- What surprised you in particular?
- What other findings did the investigation provide?
- Why are these inversions so important?
- How can breeding benefit from these new findings?
- Ultimately, it's all about preparing barley for the challenges posed by climate change, isn't it?
- What challenges are still ahead of you?
- What to eat in Mumbai
- How is tapioca pudding made?
- What is a bicycle pickup
- What do the British call a bathroom
- When should I italicize titles
- How much do Pokemon TCG cards cost
- Is Quora searchable
- What is a qualifier in C.
- The Thing is a remake in 1982
- What is hair loss treatment 1
- Why was Path launched without Facebook integration
- How is the ITS Dental College Murad Nagar
- What was your first scenario for everyone dies
- How is the service from Ways2capital company
- What are some great Japanese ballads
- What could graphene make waterproof?
- Can emancipate a child from a parent
- Why does my mix sound so hard
- Which is more important responsibility or justice
- Why do mostly boys play Fortnite
- What is the currency in the Congo
- When does the Age of Reason begin?
- Where can I buy Arduino Galileo
- How much does music cost properly