Is temazepam for anxiety


TemazepamDrug groupsBenzodiazepineTemazepam is an active ingredient from the group of benzodiazepines with a sleep-promoting and calming effect. It is used for sleep disorders and for premedication. Temazepam can be addictive and should only be taken for a short time. Possible adverse effects include fatigue, confusion, amnesia, and personality changes, among others.

synonymous: TemazepamumPhEur

Products

Temazepam is commercially available in the form of capsules (Normison®). It has been approved in Switzerland since 1983.

Structure and properties

Temazepam (C.16H13ClN2O2, Mr = 300.7 g / mol) is a white, crystalline powder that is practically insoluble in water. It is present in drugs as a racemate (hydroxyl group). Temazepam is one of the 5-aryl-1,4-benzodiazepines.

Effects

Temazepam (ATC N05CD07) has anti-anxiety, calming, sleep-inducing, antispasmodic and muscle-relaxing properties.

Mechanism of action of the benzodiazepines, click to enlarge. Illustration © PharmaWiki

Indications

For the short-term treatment of sleep disorders in adults. For premedication in adults.

abuse

Temazepam, like all benzodiazepines, can be misused as a sedating and relaxing intoxicant.

dosage

The medicine is taken immediately, no more than 30 minutes before going to bed. The duration of the therapy should be kept as short as possible and should not exceed 4 weeks.

Contraindications
  • Hypersensitivity
  • Myasthenia gravis
  • Severe respiratory failure
  • Sleep apnea

The complete precautionary measures can be found in the medicinal product information sheet.

Interactions

Central depressant drugs and substances such as alcohol, intoxicants, psychotropic drugs, sleeping pills, anti-anxiety drugs, opioids, anti-epileptic drugs and antihistamines can increase the depressant effects of temazepam.

unwanted effects

Occasionally, indigestion, muscle weakness, gait disorders, decreased libido, skin reactions, visual disturbances, drowsiness, lack of sensation, reduced ability to react, states of confusion, tiredness, headache, dizziness can occur.

Anterograde amnesia, depression, and changes in blood count are rare. Temazepam, like other benzodiazepines, can be addictive and tolerance can develop with prolonged treatment.

see also

Benzodiazepines

literature
  • Medicinal product information (CH)
  • Dwyer R. Privileging pleasure: temazepam injection in a heroin marketplace. Int J Drug Policy, 2008, 19 (5), 367-74 Pubmed
  • European Pharmacopoeia PhEur
  • Fraschini F., Stankov B. Temazepam: pharmacological profile of a benzodiazepine and new trends in its clinical application. Pharmacol Res, 1993, 27 (2), 97-113 Pubmed
  • Heel R.C., Brogden R.N., Speight T.M., Avery G.S. Temazepam: a review of its pharmacological properties and therapeutic efficacy as an hypnotic. Drugs, 1981, 21 (5), 321-40 Pubmed
  • McElnay J.C., Jones M.E., Alexander B. Temazepam (Restoril, Sandoz Pharmaceuticals). Drug Intell Clin Pharm, 1982, 16 (9), 650-6 Pubmed
author

Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.

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This article was last changed on April 15, 2020.
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