Does the wheat germ go bad

Staying Young with Spermidine?


Liang YT et al. (2021): eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Cell Rep. 2021 Apr 13; 35 (2): 108941.

Schroeder S. et al. (2021): Dietary spermidine improves cognitive function. Cell Rep. 2021 Apr 13; 35 (2): 108985.

Lenzen-Schulte, M .; Zylka-Menhorn, V. (2016): Autophagy: "Self-mutilation" as a survival strategy. Dtsch Arztebl 113 (40): A-1740 / B-1469 / C-146.

Arznei-Telegram (2020): ANTI-AGING WITH SPERMIDINE? a-t 2020; 51: 38-9

Smollich, M. [blog entry] (2020): Charité study: With spermidine against COVID-19. Nutritional medicine blog, published on April 23, 2020.

Neuwirth, N [blog entry] (2020): Spermidine: fasting without giving up? Nutritional medicine blog, published on April 22nd, 2020

Soda, K. et al. (2009): Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations. J Nutr Sci Vitaminol 55, 361-366

Madeo et al. (2019): Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019; 15 (1): 165-168

Published online 2018 Oct 11. doi: 10.1080 / 15548627.2018.1530929,

Gassen, N. et al. (2020): Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics. doi:

Eisenberg T, Knauer H, Madeo F et al. (2009): Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 11 (11): 1305-14

Kiechl S, Pechlaner R, Willeit P, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. At J Clin Nutr. 2018 Aug 1; 108 (2): 371-380

Schwarz, C. et al. (2018): Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline Aging (Albany NY). 2018 Jan; 10 (1): 19-33

Implementing Regulation (EU) 2020/443 of the Commission of March 25, 2020 approving the amendment of the specifications of the novel food wheat germ extract (Triticum aestivum) with a high spermidine content