What is meant by cervical syndrome
Milgamma injections - indications for use, effect, side effects, reviews of the drug
Hello my good guys! A neighbor came in today to exchange news. Her husband was taken to the hospital on his back and the injections were prescribed.
She asked me if the good guys would help or not. Well I think the doctors know better since they prescribed it, it means they are counting on it to work. This drug is a combination of B vitamins so there definitely won't be any harm.
To reassure her, she found instructions for use and gave reviews to read those treated with this drug. It seems to have calmed down, she picked up the transfer. And from myself I will put a jar of ointment on herbs.
Milgamma is a complex preparation that contains group B vitamins. The drug is available in various forms, both for oral use and in solution for injection. The main purpose of the drug is the therapy of neurological pathologies, which are accompanied by impaired conduction of impulses in the nervous tissue.
The effectiveness of the drug in the complex treatment of diseases and pathologies of the musculoskeletal system is due to the action of B vitamins on inflammatory and degenerative processes and pain relief.
Instructions for use Milgamma describes general recommendations on the dosage, frequency and duration of the course of treatment, so the drug is taken only after consulting a doctor in accordance with the individual prescription.
The drug Milgamma is prescribed by a doctor to relieve severe inflammation and pain in nerve tissue. Taking this drug improves blood circulation, microcirculation and the nervous system.
The composition of Milgamma includes useful vitamins of group B. They relieve the inflammatory process and restore the activity of the motor apparatus. Vitamins B1, B6 and B12 restore nerve tissue and improve general blood flow to the body.
In the market, the drug is available in two forms: coated tablets and injection. The injection form is considered preferred due to its rapid penetration into the bloodstream and increased absorption and exposure, with the exception of processing factors of the components of the drug in the digestive tract.
Milgamma Compositum in the form of tablets for oral administration and a solution for injection have differences in the composition of the drug. The composition of the ampoules includes:
- Sodium polyphosphate.
- Benzyl alcohol.
The composition of the tablets includes the following substances:
- Pyridoxine hydrochloride.
- Silicon dioxide.
- Croscarmellose sodium.
The Milgamma drug contains neurotropic vitamins that belong to group B. The drug is used at a therapeutic dose in diseases of the nerves and nervous tissue, in which patients have a violation of nerve conduction or inflammatory and degenerative phenomena.
The drug Milgamma is also prescribed for people with diseases of the musculoskeletal system. The use of a drug containing large doses of vitamin B relieves severe pain, activates microcirculatory processes, improves blood formation and the nervous system.
Pharmacological effect - analgesic, neuroprotective, metabolic.
Vitamin B1 (thiamine) is converted into cocarboxylase and thiamine triphosphate through phosphorylation when ingested. Cocarboxylase, in turn, is involved in the processes of carbohydrate metabolism, normalizes the functions of nerve tissue and nerves, and improves nerve conduction.
When the body is deficient in vitamin B1, underoxidized products of carbohydrate metabolism can accumulate in tissues and cause a variety of pathological conditions.
When determining which is better - injections or milgamma tablets - it should be borne in mind that instead of thiamine, tablets contain benfothiamine, a fat-soluble derivative of thiamine.
Vitamin B6 (pyridoxine) is phosphorylated when ingested. The products of its metabolism are involved in the decarboxylation of amino acids, as a result of which physiologically active mediators are produced in the body - adrenaline, histamine, tyramine, dopamine, serotonin. Vitamin B6 also affects the tryptophan metabolism.
Vitamins B1 and B6 strengthen the mutual influence, therefore Milgamma vitamins in injections and tablets have a clearly positive effect on the health of patients with diseases of the nerves and motor apparatus.
Vitamin B12 (cyanocobalamin) has an anti-anemic effect and activates the synthesis of nucleic acids, choline, creatinine and methionine. It is involved in metabolic processes in cells. The substance reduces pain as a result of damage to the peripheral NS and activates the nucleic acid metabolism.
Lidocaine has a local anesthetic effect.
After v / m administration, thiamine is quickly absorbed from the injection site and enters the bloodstream (484 ng / ml after 15 minutes on the first day of a 50 mg dose) and is unevenly distributed in the body if it is contained in leukocytes - 15 %, Erythrocytes - 75%, and in plasma - 10%. Due to the lack of significant vitamin reserves in the body, it must be taken on a daily basis.
Thiamine crosses the blood-brain and placental barriers and is found in breast milk. Thiamine is excreted in the urine in the alpha phase after 0.15 hours, in the beta phase after 1 hour and in the end phase within 2 days. The main metabolites are: thiamine carboxylic acid, pyramine and some unknown metabolites.
Of all vitamins, thiamine is stored in the body in very small quantities. The adult body contains about 30 mg of thiamine in the form of thiamine pyrophosphate (80%), thiamine triphosphate (10%) and the rest in the form of thiamine monophosphate.
After intramuscular injection, pyridoxine is quickly absorbed into the bloodstream and distributed throughout the body, acting as a coenzyme after phosphorylation of the CH2OH group in the 5th position. About 80% of the vitamin binds to plasma proteins.
Pyridoxine is distributed throughout the body, crosses the placenta and is found in breast milk, is deposited in the liver and is oxidized to 4-pyridoxic acid, which is excreted in the urine a maximum of 2–5 hours after absorption. The human body contains 40–150 mg of vitamin B6 and its daily rate of elimination is around 1.7–3.6 mg with a replenishment rate of 2.2–2.4%.
Indications and contraindications
Indications of the drug Milgamma® as a pathogenetic and symptomatic agent in the complex treatment of diseases and syndromes of the nervous system of different origins:
- Paresis of the facial nerve;
- retrobulbar neuritis;
- Ganglionitis (including herpes zoster);
- Polyneuropathy (including diabetics, alcoholics);
- Night muscle cramps, especially in people of older age groups;
- neurological manifestations of osteochondrosis of the spine: radiculopathy, lumbar ischalgia, muscle tone syndromes.
Distinguish the use of drugs for relief of acute attacks and in the course of therapy. For pain relief, a single dose of 2 ml (one ampoule) is prescribed intramuscularly.
The duration of therapy for acute attacks depends on the patient's condition. The injections are given daily until stable. Maintenance treatment is carried out at a dose of 2 ml per injection with a frequency of every other day.
- Increased individual sensitivity to thiamine, benfotiamine, pyridoxine or other components of the drug.
- Pregnancy and breast feeding period.
- Childhood due to lack of data.
- Decompensated heart failure.
Each tablet contains 92.4 mg sucrose. Therefore, the drug should not be used in people with congenital fructose intolerance, glucose and galactose malabsorption syndrome, or glucose-isomaltose deficiency. Decompensated heart failure.
If you suffer from any of the listed diseases, be sure to consult a doctor before taking the drug.
The frequency of undesirable side effects is given according to the WHO classification: very common (more than 1/10); often (less than 1/10 but more than 1/100); rarely (less than 1/100 but more than 1/1000); rarely (less than 1/1000 but more than 1/10000); very rare (less than 1/10000), including isolated cases (symptoms occur with an unknown frequency).
- On the part of the immune system: rarely - allergic reactions (rash, shortness of breath, anaphylactic shock, Quincke's edema).
- From the side of the nervous system: in some cases - dizziness, confusion.
- From the CCC side: very rarely - tachycardia; in some cases - bradycardia, arrhythmia.
- From the digestive tract: in some cases - vomiting.
- From the side of the skin and subcutaneous tissues: very rarely - increased sweating, acne, itching, urticaria.
- From the side of the musculoskeletal system and connective tissue: in some cases - convulsions.
General disorders and disorders at the injection site: In some cases irritation at the injection site may occur, systemic reactions are possible with rapid administration or with overdose.
Given its wide therapeutic range, oral benfotiamine overdose is unlikely.
Ingestion of high doses of pyridoxine (vitamin B6) over a short period of time (at a dose greater than 1 g per day) can lead to short-term neurotoxic effects. With more than 6 months of using the drug at a dose of 100 mg when tapping, neuropathies are also possible.
Overdose usually manifests itself in the development of sensory polyneuropathy, which can be accompanied by ataxia. Taking the drug in extremely high doses can cause cramps. In newborns and infants, the drug can have a powerful sedative effect, cause hypotension and respiratory failure (dyspnea, apnea). Overdose treatment.
If pyridoxine is taken in a dose greater than 150 mg / kg body weight, it is recommended to induce vomiting and to take activated charcoal. The provocation of vomiting is most effective in the first 30 minutes after taking the drug. Emergency measures may be required.
If any of these side effects get worse, or if you experience any other side effects not listed in the instructions, you should tell your doctor.
Interaction with other drugs
Thiamine decomposes completely in solutions containing sulfite. As a result, thiamine breakdown products inactivate the effects of other vitamins.
Thiamine is incompatible with oxidizing and reducing compounds, including iodides, carbonates, acetates, tannic acid, ammonium iron citrate, phenobarbital, riboflavin, benzylpenicillin, dextrose, disulfites. Copper accelerates the destruction of thiamine; In addition, thiamine loses its effectiveness when the pH levels rise above 3.
Therapeutic doses of pyridoxine attenuate the effects of levodopa (the anti-Parkinsonian effects of levodopa are reduced) while ingestion. An interaction with cycloserine, penicillamine and isoniazid is also observed ..
With the parenteral use of lidocaine with the additional use of noradrenaline and adrenaline, an increase in side effects on the heart is possible. An interaction with sulfonamides is also observed ..
Cyanocobalamin is incompatible with heavy metal salts. Riboflavin also has a destructive effect, especially when exposed to light; Nicotinamide accelerates photolysis, while antioxidants have an inhibitory effect.
Storage and sales conditions
Storage conditions: At a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life: 5 years. Do not use after the expiration date.
Approval form. Solution for intramuscular injection:
- 2 ml in ampoules made of brown light-protective hydrolytic glass type I, a label is applied to each ampoule and a white dot with paint is applied.
- 5 ampoules in a PVC blister pack. 1, 2 or 5 blisters are placed in a cardboard box.
- 5 ampoules in a cardboard tray with dividers. 1 or 5 cardboard pallets are placed in a cardboard bundle.
- 10 ampoules in a cardboard tray with dividers. 1 cardboard pallet is placed in a cardboard bundle.
The coated tablets are packed in 30 or 60 pieces. Milgamma Compositum tablets are also produced - biconvex, round, white. The dragee is contained in a 15-piece blister pack. There can be 2 or 4 bubbles in a bundle of cardboard.
Pharmacy leave conditions - prescription.
Special instructions for use
If the patient is prescribed Milgamma injections, the instructions for use should be carefully followed. Initially, the drug is administered 2 ml deep into the muscle once a day for 5-10 days. If the injections are intended for maintenance therapy, 2 ml is given 2-3 times a week. You can also take the drug in pill form for maintenance therapy (1 tablet daily).
Milgamma's instructions for use indicate that for the rapid elimination of pain, ampoules or tablets should be used (1 tablet three times a day). Treatment can last about a month.
The doctor should monitor the patient's health on a weekly basis. Experts advise switching to taking the drug internally as soon as possible. Please note that no Milgamma candles will be issued.
Before using the drug, the doctor should familiarize himself with the list of special instructions. Thiamine is destroyed in solutions with sulfites. The breakdown products of thiamine reduce the effects of other vitamins. Thiamine is incompatible with iodides, acetates, tannic acid, phenobarbital, riboflavin, dextrose, benzylpenicillin and disulfites.
Copper accelerates the destruction of thiamine. Pyridoxine weakens the effects of levodopa in Parkinson's disease. Also reduces the effects of cycloserine, penicillamine, isoniazid. If lidocaine is used at the same time as adrenaline compounds, the side effects on the heart muscle may increase. The same thing happens when used with sulfonamides ..
Vitamin B 12 is not compatible with heavy metal compounds. Riboflavin can also destroy vitamin B12. Antioxidants have an inhibiting effect. In the case of accidental intravenous administration, the person should be under the supervision of a doctor or be hospitalized. There is no reliable information on its effect on the rate of psychomotor reactions.
The course of treatment with injections can be longer only if prescribed by a doctor. Your doctor should also ask how often injections can be injected and which form of release is preferred in each case. The drug is prescribed to adolescents only from the age of 16.
Milgamma is prescribed after alcohol intoxication to restore the body. At the same time, alcohol and milgamma should not be consumed, both in injections and in tablets.
Despite the fact that the compatibility of this drug with alcohol is not described in the official instructions, such a combination will completely neutralize the positive effect of using the drug. A combination of alcohol and lidocaine can also cause a number of side effects: headache, drowsiness, anxiety.
Analogues of the drug
Doctors may also prescribe another drug that is similar in effect and composition to Milgamma. The drugs listed below are analogues of Milgam. By analogues we mean medicinal products that have the same international unprotected name or ATC code. Most often, such analogs are used:
- Complex B1.
- Neurolek in the form of ampoules.
- Neuromax tablets.
Vitaxon. Indications: For neurological diseases caused by a proven deficiency of vitamins B1, B6.
Cocarboxylase. Indications: acidosis (acidification) and pre-comatose state (incomplete loss of consciousness - the initial stage of coma development, characterized by the maintenance of pain and reflex reactions) in diabetes.
Disorders of cardiovascular activity (changes in heart rate, extrasystole / disturbance of the heart rhythm /, bigeminy / disturbance of the heart rhythm, characterized by alternation of normal and pathological contractions /), paroxysmal tachycardia / sudden increase in the pulse of unknown origin /) and the coronary (through the vessels of the heart) blood flow. Heart attack.
Complex B1 B6 B12.Indications: Symptomatic therapy of diseases of the nervous system of various origins: neuritis, neuralgia, polyneuropathy (diabetic, alcoholic), myalgia, radicular syndromes, retrobulbar neuritis, herpetic lesions (herpes zoster), paresis of the facial nerve, systemic neurological diseases due to proven vitamin deficiencies1 B6 and B12 .
Neurobion. Indications: For maintenance therapy of neuritis and neuralgia, such as: trigeminal neuralgia; intercostal neuralgia; Sciatica; Lumbar plexitis syndrome (lumbago) (cervical and brachial plexus), radicular neuritis due to degenerative diseases of the spine; Prosoplegia (facial nerve damage).
Neuromultivitis. Indications: Neurological diseases of various origins: polyneuropathies of various causes (especially endotoxic or ekzotoksichny, including diabetics, alcoholics), neuritis and neuralgia, radiculoneuritis due to degenerative diseases of the spine, paralysis of the cervical spine, shoulder rotator compression syndrome, lumbar neuralgia, nerve neuralgia, sciatica.
Neurorubin. Indications: diseases related to chronic alcohol consumption (peripheral neuropathy, Wernicke-Korsakov syndrome), diabetic polyneuropathies; take-take (dry and wet). As additional treatment: acute or chronic neuritis and the area of neuritis; Trigeminal neuralgia, cervicobrachial neuralgia, sciatica.
Nerviplex. Indications: Neurological disorders due to lack of vitamins B1, B6 and B12: peripheral neuropathy, diabetic neuropathy, alcoholic neuritis field, polyneuropathies of various etiologies, neuritis and neuralgia (sciatica, lumbago, plexitis, intercostal neuralgia, paresis of the facial nerve, neurological damage and state of different etiology) .
Neurobeks. Indications: Nonspecific and degenerative diseases of the peripheral nerves - neuritis, the area of neuritis (alcoholic, after infectious, toxic, diabetes), peripheral paralysis, neuralgia, paresthesia of polyneuropathy, encephalopathy, asthenia, myasthenia gravis, osteochondrosis, lumbago, sciatica -vascular.
Spastic conditions of central origin, traumatic injuries to the central nervous system, autonomic neurosis, chorea, Wernicke encephalopathy, chronic alcoholism, intoxication. Hypovitaminosis of vitamins B1, B6, B12.
In combination therapy for: degenerative processes in the retina, glaucoma, diabetic retinopathy, macular degeneration, optic neuritis, toxic damage to the optic nerve, auditory nerve neuritis, sensorineural hearing loss, toxic and medicinal damage to the auditory nerve, dermatitis, psoriasis of various aetiologies, psoriasis of various etiologies, psoriasis , Alopecia; Gastric ulcer of the stomach and duodenum, gastritis, duodenitis, enterocolitis, pancreatitis, hepatitis.
Unigamma indications: Symptomatic treatment of diseases of the nervous system of different origins: the area of neuropathy of various etiologies, neuritis, neuralgia, sciatica as a result of degenerative diseases of the spinal cord, intercostal neuralgia, trigeminal neuralgia, sciatica, shoulder syndrome, lumbago, cervical syndrome, facial paresis.
It is not recommended to use such funds yourself. You can drink one tablet to relieve severe pain, but consult a doctor immediately. Only he will prescribe the correct drug for the patient's diagnosis ..
Reviews about the drug
There are numerous reviews of Milgamma left by both patients who have undergone such treatment and specialists. The reviews state that the injections intramuscularly are painful enough, sometimes irritation is noted at the injection site.
More often, however, the positive effect is described in the treatment of neuralgia, neuritis and other diseases noted after the injection of milgamma injections to the patient. Reviews of doctors contain information that patients should lead a correct lifestyle during treatment and follow all recommendations, since the remedy only removes the symptoms, not the cause of the discomfort.
Often, the effectiveness of the drug is also established in the complex therapy, for which not only this drug, but also other drugs are prescribed. For example, a good effect can be achieved if Movalis and Milgamma are appointed at the same time. Movalis is a non-steroidal anti-inflammatory drug that has an extremely positive effect on diseases of the musculoskeletal system.
Anatoly Snezhan, Gomel. Prescribed 10 pieces yesterday. 2 ml per day - intramuscularly, inject independently (instead of part of the drug for intravenous injection by a day clinic recommended by diabetes doctors). Most likely, I'll prick closer to the New Year in the fall. Most likely, we will buy a second set - for the woman.
I want to try a combination of two i / m drugs - Movalis and Milgamma. I read about the first one - so that there would be a minimum of contraindications. There are two reasons (main) - type 2 diabetes, the neck and lower spine are very sore, other joints including hands.
Cramps of the feet, more precisely the fingers). I am sure that it will be easier because of the need for B vitamins such as potassium, magnesium. I have found that with the SMALL touch of microbial bacteria, I get sick instantly and severely.
Rufim. The advertised drug, of course. At first he doubted he would solve my problems. However, in fact, it gave really positive results. Besides, it didn't just help me. We use it as a family course, strictly following the instructions for use. Satisfied with the low price, it is just a godsend for our large family!
Has proven itself perfectly for a year. It restores strength and relieves stress after a hard day's work. This is very important when you have a large family. I stab him right in the brain and after that nothing bothers me. Thanks to the manufacturer!
Venus. My husband grabbed his back and lay in my bed. At first I rubbed Voltaren on it, but there was no effect. He spoke, not even stunned. I had to go to the pharmacy again, advised the pharmacist Milgammu. Gave him pills, it helped, got up in a few days. Now we always keep it in the medicine cabinet just in case.
Alevtina. The sciatic nerve regularly pinches me, the doctor diagnosed neuralgia, but where did it come from, this neuralgia - who knows, did an X-ray and MRI scan and, thank God, did not find any hernias and formations.
The doctor said not to lift the weight, of course I try, but with a young child this is still inevitable. I try to drink Milgamma tablets that he regularly prescribed that left the pain for a long time and now I am treated in courses.
Tamara Of course you can do experiments on yourself, but I prefer tried and tested brands. Here Milgamma is a wonderful remedy for osteochondrosis, how often has it helped me. And no side effects. And in tablets it is convenient to inject vitamins or take a pill at home - there is a difference.
Caroline. It seems to me that now there are no people without osteochondrosis, except athletes. The rest of them sit in a computer and lead a sedentary lifestyle. Women also conceive with additional stress on the spine.
In general, I came to the conclusion that pills that support the spine and prevent seizures are also useful for prevention. I respect Milgammu compositum, mostly for the back, it started running to a neurologist much less often.
Valentine's Day In the past year she was on sick leave twice. There are such recordings that it is difficult not only to sit in the office at work, but also to lie at home. Both times Milgamma tablets were saved, as soon as I start drinking it instantly relieves the pain. I think we should start drinking already. Prevention is better than suffering from such exacerbations.
Alexei. Has anyone compared the agricultural properties of Milgamma to, for example, a Neurobion or a Binavit? I've compared as much as I could, I'm not a paramedic, but there are problems with my back and leg. In addition to similar properties, Milgamma wins due to the content of B vitamins, which not only has a positive effect on the focus of the disease. I'm not smart, just someone doesn't know)
Stella. I drink Milgammu compositum once a day, one tablet and exactly one month, then a break of six months and then again. And now, against the background of such prevention, in the second year I no longer have a single crisis with my back. And before that, before such prophylaxis, I was cool twice a year ...
Svetlana Hello, I want to share a review on Milgamme week the doctor first went to the surgeon, but the surgeon sent to the neurologist.
As a result of the diagnosis, pinched nerve (in plain language). They prescribed injections, powders, and physical therapy. It is good that I can give injections myself. After three days when I started to feel my finger the injections are not painful (maybe I'll do them myself)))) thanks to my doctor and Milgamma. Take care and be healthy!
Vasily Ignatievich. Milgamma is just a warehouse for Group B vitamins. Previously, they were discontinued separately as you had to take care of your diseased spine. As soon as I found out about Milgamma, I switched to him immediately, conveniently drank a pill and received the necessary vitamins. And my back hurts a lot less.
Naira. As far as I can remember, my back is suffering. It seems to me that everything hurts there - from the neck to the tailbone. Then clamped between your shoulder blades so you want to climb the wall, then shoot in the lower back. To be honest, I am no longer treated, I made up. So sometimes I smear something. But I still drink Milgamma regularly. This is the only thing that relieves me and believes in its effectiveness. Verified help.
Milgamma - instructions for use, analogs, price, reviews
The website contains reference information for informational purposes only. Diagnosis and treatment of diseases should be done under the supervision of a specialist. All drugs have contraindications. Expert advice required!
About the drug
Milgamma contains therapeutic doses of B vitamins. Vitamins of this group are used to treat pathologies of nervous tissue and diseases of nerves of various origins, in which inflammatory and degenerative changes occur, along with impaired nerve conduction. The drug is used in neurological practice and partly also in orthopedics - to treat pathologies of the musculoskeletal system. Group B vitamins improve blood circulation and blood formation, stabilize the functioning of the nervous system and, in high doses, help relieve pain.
Thiamine (also known as vitamin B1) is converted to cocarboxylase when it is metabolized. Normal conversion of the carbohydrate metabolism is not possible without cocarboxylase, which in turn has a negative effect on the function of the nervous tissue. The lack of thiamine in the body is fraught with the accumulation of carbohydrate metabolites, which leads to various pathologies.
The composition of the tablet form of the drug contains the substance benfotiamine instead of thiamine hydrochloride. This substance is also involved in the metabolism of carbohydrates.
Pyridoxine - another group B vitamin - is involved in the metabolism of amino acids in the metabolism and in the synthesis of active mediators of the body:
Vitamin B6 is also involved in hemoglobin formation processes.
Vitamin B12 (or cyanocobalamin) acts as an anti-anemic; stimulates the synthesis of substances such as:
- Nucleic acids,
It takes an active part in cell metabolism. Also an analgesic.
Thiamine is excreted in the urine; not accumulated in body tissue.
Cyanocobalamin actively binds to albumin after it enters the blood plasma. It accumulates in the bone marrow and easily penetrates the haematoplacental barrier.
Instructions for use
- Recovery action.
- Neuritis and neuralgia, including retrobulbar neuritis.
- Alcoholic or diabetic polyneuropathy.
- Herpes virus infections.
- Paresis of the facial nerve.
Studies of the effectiveness of Milgamma in patients with:
- Multiple sclerosis;
- Brain pathology;
These studies showed a significant reduction in pathological symptoms:
- normal function of organs and blood vessels,
- Concentration has improved
- Vitamin B deficiency disappeared.
Instructions for use of the drug in the form of tablets and injections (for injections)
The duration of therapy with Milgamma is 1 month.
Milgamma Composite is the same drug, it is only available in the form of a dragee, and not in the form of tablets or a solution for injection. It has the same indications and the same composition ..
- Quincke's edema,
- Shortness of breath,
Usually these symptoms develop if the drug is administered parenterally too quickly or if the dosage is inappropriately high.
- Children and adolescents under 16 years of age.
- Hypersensitivity to B vitamins.
- Violation of the conduction processes of the heart muscle.
- Heart failure.
Milgamma is not recommended for use during pregnancy and breast-feeding as studies of its effects on the development of the fetus have not been performed.
The age limit for taking the drug is 16 years. Children under this age are not prescribed.
An interaction with sulfate solutions is excluded - thiamine decomposes completely in such cases. When thiamine metabolites appear, inactivation of other vitamins in the preparation begins.
Thiamine is inactivated when:
- Mercury chloride,
- Ammonium citrate,
- Tannic acid,
Its activity decreases with increasing pH and in the presence of copper.
Pyridoxine decreases the effectiveness of anti-Parkinsonian drugs, especially levodopa. Your application shouldn't coincide in time. In the presence of certain heavy metal salts, the inactivation of cyanocobalamin begins.
An overdose of Milgamma is associated with an increase in the symptoms of side effects. With such signs, symptomatic therapy is carried out.
Release forms - ampoules and tablets
The drug is available in two dosage forms: ampoules and tablets.
The drug does not affect the speed of psychomotor reactions. When you use it, you can drive vehicles.
- Milgamma composite.
- Milgamma, ampoules of 2 ml for injection, 5 pieces in a pack - from 219 to 428 rubles;
- Tablets, 30 pieces per pack - 300 - 557 rubles.
Olga, 34 years old.
I had facial neuritis - very uncomfortable and painful. Comprehensive treatment was prescribed - and physical therapy, plus vitamins for general toning (including Milgamma) and facial exercises. The left side of my face was just numb, it's such an uncomfortable feeling. Thanks to Milgamma and other drugs that the neurologist prescribed for me, the neuritis has disappeared.
Natalya, 40 years old.
I have diabetic polyneuropathy - the sciatic nerve is affected and this is a chronic form that cannot be treated. The maximum that can be done is to ease the condition slightly. Well, here is Milgamma and I'm saving, it's a great neurological drug.
Yana Nikolaevna, 49 years old.
I have myalgia. Because of her, I often feel dull, pressing pain. He complained to his family doctor and advised that Milgamma be injected intramuscularly. This tool partially stuns and for the most part eliminates all types of violations. I checked myself whether the drug was really effective.
Pavel, 38 years old.
My wife and I recently reached out to a neurologist - I had neuritis and had to undergo treatment. Movalis was stabbed to me first, but he's so sick he's scared. He asked the doctor to replace Movalis with another drug. He appointed the Milgamma. Well, of course, this better drug doesn't hurt that much. Neuritis is gone, but unfortunately there are consequences.
What good is Milgamma.Instructions, reviews and analogues, the price in pharmacies
A multivitamin drug with neuroprotective, metabolic, and anesthetic effects is Milgamma. The instructions for use explain how to take pills (coated tablets), injections (injections in ampoules) for the treatment of osteochondrosis, neuralgia in adults, children and pregnancy. The article also presents what Milgamma helps out of, pricing information, analogues and patient reviews.
Release form and composition
The drug is available in the form of a solution (Milgamma injections for intramuscular injection), as well as tablets and dragees.
Vitamins in the form of a solution are contained in 2 ml ampoules. The ampoules are made of brown hydrolytic glass, each has a label and a white dot. In the package - 5 or 10 ampoules.
Coated tablets packed in 30 or 60 pieces.
Milgamma Compositum tablets are also produced - biconvex, round, white. The dragee is contained in a 15-piece blister pack. There can be 2 or 4 bubbles in a bundle of cardboard.
The composition of the milgamma in the form of a solution for intramuscular administration contains several active substances. In particular, the composition of the ampoules includes: pyridoxine hydrochloride, thiamine hydrochloride, cyanocobalamin, lidocaine hydrochloride.
Milgamma injections also contain additional substances: benzyl alcohol, potassium hexacyanoferrate, sodium hydroxide, sodium polyphosphate, water for injection.
Vitamins in tablets contain benfothiamine, pyridoxine hydrochloride and anhydrous colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, talc, povidone K30 and, in some cases, long-chain glycerides.
Please note that no Milgamma candles will be issued.
Group B neurotropic vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and musculoskeletal system. In large doses, they have not only a substitutional effect, but also a number of pharmacological effects: analytical, anti-inflammatory, microcirculatory.
- Vitamin B1 in the form of thiamine diphosphate and thiamine triphosphate plays a key role in carbohydrate metabolism and is a coenzyme made up of pyruvate decarboxylase, 2-oxoglutarate dehydrogenase and transketolase. In the pentose phosphate cycle, thiamine diphosphate is involved in the transfer of aldehyde groups.
- Vitamin B6 in its phosphorylated form (pyridoxal-5-phosphate) is a coenzyme of numerous enzymes that are mainly involved in the metabolism of amino acids as well as carbohydrates and fats.
- Vitamin B12 is important for cell metabolism, blood formation and the functioning of the nervous system. It stimulates the nucleic acid metabolism via folic acid activation. In large doses, cyanocobalamin has analgesic, anti-inflammatory, and microcirculatory effects.
- Lidocaine - local pain reliever.
Although it is a vitamin, the drug is used not in case of a lack of vitamins in the body, but in diseases of the nervous system that appear with symptoms of pain.
Why is Milgamma prescribed: indications for use
Milgamma is used as a symptomatic and pathogenetic agent in the complex therapy of the following syndromes and diseases of the nervous system:
- Neuritis, neuralgia;
- Retrobulbar neuritis;
- Ganglionitis (including herpes zoster);
- Polyneuropathy (diabetics and alcoholics);
- Paresis of the facial nerve;
- Night muscle cramps, especially in the elderly;
- Systemic neurological diseases due to deficiency in vitamins B1 and B6.
- Neurological manifestations of osteochondrosis of the spine: lumbar sciatica, radiculopathy (radicular syndrome), muscle tone syndromes.
Instructions for use
If the patient is prescribed Milgamma injections, the instructions for use should be carefully followed. Initially, the drug is administered 2 ml deep into the muscle once a day for 5-10 days. If the injections are intended for maintenance therapy, 2 ml is given 2-3 times a week. You can also take the drug in pill form for maintenance therapy (1 tablet daily).
Milgamma's instructions for use indicate that for the rapid elimination of pain, ampoules or tablets should be used (1 tablet three times a day). Treatment can last about a month. The doctor should monitor the patient's health on a weekly basis. Experts advise switching to taking the drug internally as soon as possible.
The course of treatment with injections can be longer only if prescribed by a doctor. You should also ask your doctor how often injections can be injected and what form of release is preferable in each case.
It is contraindicated to prescribe Milgamma in the following cases:
- Patients with sensitivity to drug components.
- With violations in the work of the heart muscle.
- Children under 16 years.
- In acute heart failure.
- For patients with frequent attacks of allergies.
Vitamin B12 as part of the drug is prohibited in thromboembolism and erythremia. Vitamin B6 in a medicine is dangerous for stomach ulcers.
- Allergy manifestations: rashes, bronchospasm, anaphylaxis, angioedema, urticaria.
- Nervous system dysfunction: dizziness, impaired consciousness.
- Circulatory disorders: tachycardia, slowdown or arrhythmia.
- Indigestion: vomiting.
- Skin and soft tissue reactions: hyperhidrosis, acne.
- Musculoskeletal dysfunction: convulsive syndrome.
- Injection site reactions: irritation.
Systemic reactions can develop from rapid administration or overdose.
Use during pregnancy and breastfeeding
Due to the lack of data on the effect of the drug on the fetus, it is not prescribed to expectant mothers. In addition, it is not recommended for use during breastfeeding.
How to prescribe to children?
The drug is prescribed to adolescents only from the age of 16.
- The use of the drug during pregnancy or breastfeeding is contraindicated.
- If the drug was accidentally administered intravenously, the patient must be hospitalized or left under the supervision of a specialist.
- It is not known if the drug interferes with the ability to drive a motor vehicle or perform work that requires increased alertness.
- Under the influence of sulfites, thiamine is completely destroyed. As a result, the effects of other vitamins also cease;
- Thiamine is incompatible with oxidizing and reducing agents, including iodides, carbonates, acetates, tannic acid, ammonium iron citrate, phenobarbital, riboflavin, benzylpenicillin, dextrose, disulfites;
- under the action of copper, thiamine is destroyed more quickly;
- If the alkalinity of the medium is increased by more than pH = 3, thiamine loses its effectiveness.
- Pyridoxine can reduce the anti-Parkinsonian effects of levodopa. Similarly, the interaction occurs in combination with cycloserine, penicillamine, isoniazid;
- Norepinephrine, adrenaline and sulfonamides in combination with lidocaine increase undesirable effects on the heart;
- Cyanocobalamin is incompatible with heavy metal salts;
- Riboflavin causes the destruction of cyanocobalamin, which is amplified by the action of light;
- Nicotinamide accelerates photolysis, and antioxidant substances, on the contrary, have a depressing effect.
It should be borne in mind that when interacting with sulfonamides, vitamin B1 completely decomposes, so the effectiveness of the drug is lost. The activity of thiamine compounds also decreases in the presence of preparations containing mercury, iodine and sulfur. It is not recommended to combine with Levopoda and riboflavin.
Neuromultivitis or Milgamma: Which Is Better?
The composition of these drugs is similar, but neuromultivitis is not one of the components of lidocaine. Neuromultivitis, unlike Milgamma, is prescribed to treat children. The treating specialist explains in more detail why each of the drugs is prescribed.
Which is better: Milgamma or Combilipen?
Combilipen is also a complex vitamin drug that contains B vitamins. The drug is prescribed as part of complex therapy for patients with neurological diseases. These are similar means, only they are made by a different manufacturer, and Combiben can be bought at a lower price.
When choosing analogues, it is important to understand that the instructions for use of Milgamma, the price and reviews of drugs with similar effects are not applicable. It is important to see a doctor and not make an independent drug change.
The drug should be stored in a dark place out of the reach of children at a temperature not exceeding 15 ° C. Shelf life - 2 years.
Pharmacy leave conditions
The cost of the drug Milgamma
Price in pharmacies in Moscow: Milgamma solution 2 ml 5 pcs. - 269 to 285 rubles, 100 mg tablets of 30 pcs - from 550 to 571 rubles.
What good are injections of Milgamma
Milgamma is a drug that is widely used in neurology and other areas of medicine. The indications for its use are diverse - from pain in the spine to complications in diabetes.
Milgamma - description and composition
The pharmacological product is available in the form of a solution for injection in the form of tablets, dragees (Milgamma Compositum). Often, due to diseases of the nervous system and other pathologies, Milgamma is prescribed by injection. The red solution can be administered intramuscularly, intravenous use is not practiced.
Each ampoule contains 2 ml of Milgamma in the pack - 5 and 10 ampoules. Tablets are made in quantities of 30 and 60 pieces / pack, dragees - 15 pieces / blister, 2-4 pieces in a box. The Milgamma vitamin composition in injections is a concentrate of B vitamins:
- Thiamine (Vit. B1, thiamine hydrochloride), 100 mg;
- Pyridoxine (Vit. B6, pyridoxine hydrochloride), 100 mg;
- Cyanocobalamin (Vit. B12), 1000 µg.
Milgamma injection is very painful, as is the introduction of other drugs based on vitamin complexes. Therefore, an anesthetic is added to its composition - lidocaine hydrochloride.
Milgamma contains water, sodium hydroxide, benzyl alcohol, sodium polyphosphate, potassium hexacyanoferrate as additional ingredients.
The cost of the drug is 250 rubles. (for 5 ampoules) 630 rubles. (for 30 tablets) 1150 rubles. (for 60 tablets).
How does the drug work?
A complex remedy based on vitamins B is a neurotropic with anti-inflammatory and regenerative properties. Together, active ingredients increase blood flow and improve the function of nerve cells. Other effects that the administration or administration of the drug provides:
- Optimizing microcirculation in the blood;
- increased blood formation;
- Reduction of edema;
- general strengthening of the body;
- Normalization of vascular function.
Lidocaine in the composition is necessary not only to reduce unpleasant local reactions. This anesthetic relieves general pain syndrome and reduces the strength of the inflammatory response. The individual components of the Milgamma result in the following actions:
- Thiamine. As a natural participant in the carbohydrate metabolism, the function of the nervous tissue is impossible without a vitamin.
- Pyridoxine. Partly involved in the metabolism of carbohydrates, largely - in the metabolism of proteins, fats. Mutually enhances the effects of thiamine. In a complex, both vitamins increase the efficiency of the muscles, the cardiovascular system.
- Cyanocobalamin. Helps in the synthesis of myelin sheaths from nerve cells, reduces pain from damage to peripheral nerve trunks, and stimulates nucleic acid metabolism.
All substances penetrate the blood quickly, so that the effect can be achieved on the first day of use. B vitamins do not accumulate in the tissue, their food intake should be constant.
What does Milgamma (injections) help? As a rule, doctors prescribe a drug for the complex treatment of various local and systemic nervous diseases, including those caused by a lack of vitamins. B. As a symptomatic and pathogenetic agent, Milgamma is indicated for:
- Neuralgia of various origins;
- Paresis of the facial nerve;
- retrobulbar neuritis;
- diabetic polyneuropathy;
- alcoholic polyneuropathy;
- other types of neuropathies.
For general strengthening of the body, the administration or administration of the specified vitamin complex is indicated after serious illnesses, operations, infections and in the event of a vitamin deficiency. Night cramps are often observed in the elderly - Milgamma is used to get rid of them. Myalgia or muscle pain syndrome of various origins is also successfully stopped using Milgamma.
Due to osteochondrosis and other diseases of the spine, the drug is most often used in combination with muscle relaxants (Midokalm) and NSAIDs (Movalis and others).
The medicine worked well for herpes zoster, which is caused by the zoster virus, as well as other herpes virus infections that are localized in nerve tissue. Other indications for the use of Milgamma are sciatica, lumbago, sciatica, muscle tonic syndrome, and even multiple sclerosis.
How to use Milgamma?
If the doctor has recommended milgamma injections, then these should be done strictly in the specified amount. How long the course will last depends on the illness. So, if the cervical, thoracic or lumbar spine hurts, 5-10 injections can be prescribed daily. You can take a break from treatment at the weekend. The drug is injected deep into the gluteal muscle in an amount of 2 ml (dose for an adult).
For maintenance therapy, Milgamma is given twice or three times a week at the same dose. Such a course can last up to a month. The dosage standards for dragees and tablets are as follows:
- 1 piece / day for maintenance therapy for a month;
- 1 piece / 3 times a day for acute pain for 10 days.
You need to drink tablets with plenty of water, reception does not depend on food. After completing a pill and injection course, the doctor can extend it. This can be done if there is no risk of developing neuropathy associated with an overdose of vitamin B6 ..
The decision to treat Milgamma in a pregnant, breastfeeding woman is made by the doctor. Large doses of the drug can inhibit lactation. The drug passes into breast milk - this should also be taken into account during treatment.
Contraindications and side effects
Side effects during therapy are common, it is better to familiarize yourself with the list in advance. Basically, it is local pain in the area of administration that is observed within 2-5 hours. A rash, redness, and skin irritation may occur. Due to skin reactions in some people, they experience a general rash, itching, acne on the face, and hyperhidrosis. All "side effects" usually go away after therapy is discontinued.
Other possible body reactions to the introduction of Milgamma are:
- rarely - tachycardia;
- very rarely - bradycardia;
- very rarely - dizziness, confusion;
- Vomiting, nausea;
- Discomfort in the stomach;
- Muscle spasms.
Children are not allowed to prescribe the drug, it is allowed from the age of 18. Allergy sufferers can suffer from severe reactions - Quincke's edema, shock, generalized rashes. Similar phenomena occur with an overdose. You can not insert the drug into a vein - if it is accidentally administered, you should consult a doctor and be under his supervision for several hours. During therapy, you need to completely give up alcohol.
Analogs with milgamma injections are cheaper
The drug is expensive and therefore patients are often interested in finding a replacement in a different price range. If a patient wants to buy analogues for Milgamma, then among domestically made vitamin complexes, cheaper injections can be found. They do not differ in dosage, but the treatment regimes are the same ..
- Vitagamma is an example of complete consistency in the composition of a Russian manufacturer.There are other contraindications to these injections: these include thrombosis, an increase in red blood cells, heavy bleeding, and low blood pressure. Vitagammu is prescribed with caution and after 65 years.
- Combilipen costs only 150 rubles on average. It has fewer restrictions on use than the previous drug; In general, it is reasonable to expect the same effects from the solution for intramuscular administration as from Milgamma. Thiamine is contained in the fat-soluble form in tablets from Combilipen Tabs.
- Binavit is prescribed under the same conditions as other substitutes and has similar side effects. The drug costs about 240 rubles. Binavit Forte tablets strengthened.
- Neuromultivitis is sold in 2, 4, or 10 ampoules; The average cost is 300 rubles. The composition does not contain lidocaine, which is useful in case of allergy to the substance. The injections themselves become painful. Tablets are also offered: each contains 100 mg thiamine, 200 mg pyridoxine and 200 μg cyanocobalamin.
The pharmacy sells a lot of funds, the composition of which is similar. The exact analog of Milgamma in injections is the drug Compligam. The price of the drug is lower (130 rubles), the effectiveness is high. Analogs are also drugs in ampoules, some of the Russian production:
|Binavit||about 155 rubles per ampoule 2 ml, 10 pcs.|
Excipients: potassium hexacyanoferrate, benzyl alcohol, sodium hydroxide, sodium tripolyphosphate, water for injection.
- Thiamine hydrochloride - 50 mg;
- Pyridoxine hydrochloride - 50 mg
- Cyanocobalamin - 500 µg;
- Lidocaine hydrochloride - 10 mg.
Excipients: benzetonium chloride, disodium edetate (Trilon B), sodium hydroxide, water d /.
- Thiamine (vitamin B1);
- Pyridoxine (vitamin B6);
- Cyanocobalamin (vitamin B12);
Related substances: compounds of sodium, potassium, alcohol, water.
- Betab 20% - 50 mg;
- Yeast complex with selenium 2000 - 25 mg;
- coated ascorbic acid, type EU - 100 mg;
- α-tocopheryl acetate 50% - 80 mg.
Excipients: talc, anhydrous colloidal silicon oxide, magnesium stearate.
- Cyanocobalamin - 50 mg;
- Pyridoxine hydrochloride - 50 mg;
- Thiamine hydrochloride - 50 mg.
Excipients: sodium polyphosphate, water for injection, sodium hydroxide.
1 bottle with lyophilisate for solution for infusion contains:
- Thiamine Hydrochloride - 100.00 mg
- Pyridoxine Hydrochloride - 100.00 mg
- Cyanocobalamin - 1.00 mg
Excipients: diethanolamine 5.0 mg, water for injection up to 2.0 ml
- Thiamine mononitrate 3.1 mg;
- Riboflavin Sodium Phosphate Dihydrate 4.9 mg;
- Nicotinamide 40 mg pyridoxine hydrochloride 4.9 mg;
- Sodium pantothenate 16.5 mg;
- Sodium ascorbate 113 mg;
- Biotin 60 µg;
- Folic acid 0.4 mg;
- Cyanocobalamin 5 µg.
Excipients: glycine - 300 mg; Disodium edetate - 0.5 mg; Methyl parahydroxybenzoate - 0.5 mg.
3 ml solution contain:
- Thiamine hydrochloride (vitamin B1) 100 mg;
- Pyridoxine hydrochloride (vitamin B6) 100 mg;
- Cyanocobalamin (Vitamin B12) 1 mg.
In 2 ml solution:
- 100 mg thiamine hydrochloride;
- 100 mg pyridoxine hydrochloride;
- 1 mg of cyanocobalamin;
- 20 mg lidocaine hydrochloride.
Excipients: benzyl alcohol, sodium hexametaphosphate, potassium hexacyanoferrate, sodium hydroxide, water for injection.
- Retinol acetate 5000 IU (1.72 mg) or retinol palmitate 5000 IU (2.75 mg);
- Ascorbic acid - 70 mg;
- Thiamine chloride - 2 mg or thiamine bromide - 2.6 mg;
- Riboflavin - 2 mg;
- Pyridoxine hydrochloride - 2 mg;
- Nicotinamide - 15 mg.
Some drugs are only available in tablets, but most come in both dosage forms. The difference between the drugs at the manufacturers and the price so that you can choose the right tool and replace the Milgamma (with the doctor's approval). The drug neuromultivitis is also prescribed to children and does not contain lidocaine. It rarely causes side effects that can be considered when treating allergy sufferers.
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