Can a two-finger ulcer be completely cured

Helicobacter pylori

Infections of the stomach

The gastroscopy with tissue sampling gives you a bacterial inflammation of the stomach / duodenum was detected by the bacterial pathogen Helicobacter pylori. This infection has caused inflammation of the lining of the stomach / duodenum or even an ulcer. This infection can, but does not have to be, associated with upper abdominal complaints such as pain, nausea / nausea and / or a feeling of fullness.

It is now considered certain that this "infectious" gastric mucosal inflammation is the basis for other diseases such as duodenal and gastric ulcers. In addition, it is assumed that patients with this inflammation have an increased risk of developing gastric cancer.

A killing of the germ Helicobacter pylori can lead to a healing of the gastric mucosal inflammation. This will usually prevent the ulcer from recurring. This goes hand in hand with a rapid and clear improvement in the symptoms, in many cases with complete freedom from symptoms.

Gastrointestinal medicine has made enormous strides in the past few decades. The best example is the gastric and duodenal ulcer, which until a few decades ago not infrequently led to death by internal bleeding to death or was a frequent cause of stressful gastric operations. This practically no longer occurs today. The gastric or duodenal ulcer is a common ailment: it affects around 5-10% of the population at least once in a lifetime. The ulcer can occur in any phase of life - even in childhood or adolescence. However, people between the ages of 40 and 60 are particularly likely to get sick, and it usually doesn't stop at this one time. The ulcer disease is therefore referred to as a chronic disease.

Although this disease, due to its chronic nature with frequently recurring pain, can severely impair the quality of life, it is usually a benign disease, i.e. a disease that does not necessarily lead to death. Nevertheless, serious complications keep coming back. These can be treated better today, but they remain dangerous.

The Helicobacter pylori infection is now accepted as a decisive prerequisite for ulcer diseases and has therefore found appropriate consideration in diagnostics and therapy. The question of why, despite the enormous worldwide spread of Helicobacter pylori infection - an estimated 30% of the population over the age of 20, including in Germany - is affected only in one in ten people, needs to be clarified. It is believed that there are certain conditions in which Helicobacter pylori infection leads to ulcer in individuals while sparing others. These conditions include, on the one hand, the particular aggressiveness (virulence) of some Helicobacter pylori strains, but also genetic (familial) predispositions and the influence of certain risk factors. Examples of these risk factors are stress, anti-inflammatory drugs, as well as tobacco and alcohol. The decisive evidence for the importance of the Helicobacter pylori infection has been provided by studies which have shown that if the infection is successfully treated, the ulcer disease can be cured permanently and almost without relapses, even if the other risk factors involved in the development of the ulcer remain.

The treatment of gastric and duodenal ulcers or inflammation of the mucous membrane in this area is intended to achieve three main goals. First - most important for those affected - is rapid pain relief and elimination of any complications; then the ulcer heals, and 3. it is important to prevent relapses. The pathogen can also be detected by direct detection of the antigen in the stool. However, this method is only suitable for checking the success of therapy or healing, whereby the test should be carried out at the earliest 4 weeks after the end of taking acid-inhibiting medication. This stool test can of course be carried out here in the practice. The treatment of Helicobacter pylori infection with the so-called triple eradication therapy may appear to be quite complex in view of the relatively high number of tablets (2x 3 tablets for 1 week). Conventional long-term therapy with acid blockers, on the other hand, is only easier at first glance. This therapy, which is purely based on the symptoms of the disease, is burdened by a high number of relapses and is therefore significantly more expensive in the long run. Gastrointestinal ulcers recur in only about 2% of patients treated with triple therapy.

The currently best treatment option for Helicobacter pylori infection is the above-mentioned triple therapy by taking a proton pump inhibitor, which almost completely inhibits gastric acid production, and two antibiotics for 7 days. Thus, in large international studies, the highest cure rates were found with only a few side effects. The success rate of modern Helicobacter pylori therapy is currently 90-95% of the treated patients. It does, however, require regular and complete intake of the medication prescribed for you for a week. The prescribed proton pump inhibitor should be taken twice a day. It itself leads to a rapid improvement of the symptoms, has very few side effects and improves the effectiveness of the antibiotics. However, the actual cure for Helicobacter pylori infection is also strictly linked to the use of antibiotics. These should also be taken twice a day - together with the proton pump inhibitor - with some water before meals.

The classic three-way therapy, consisting of a so-called proton pump inhibitor and two antibiotics, is currently considered the most effective treatment for Helicobacter infection. Even if side effects should occur, they can usually be endured for a short period of just one week, as you get the great chance (90-95%) of remaining free of complaints and possible complications in the long term.

 

Therapy regimenDaily dose
Proton pump inhibitors2x1
Antibiotic 12x1
Antibiotic 22x1