What is the prognosis for lymphoma

Prognosis: What are the prospects for a cure for Hodgkin's lymphoma?

Author: Maria Yiallouros, created on: 04.02.2009, last changed: 19.06.2018

The healing rates mentioned below are statistical values. For a large group of children and adolescents suffering from Hodgkin's lymphoma, they represent an important and accurate statement. Whether or not the individual patient can be cured cannot be accurately predicted on an individual basis. However, here the statistics represent an important estimate of the probability of recovery.

Prognosis in patients with initial Hodgkin lymphoma

The chances of recovery (prognosis) for children and adolescents with Hodgkin lymphoma are very good. Over 95% of all patients, i.e. more than nine out of ten patients with Hodgkin's disease, can be cured in the long term thanks to the modern examination methods and intensive standardized combination therapies used today - regardless of how far the disease has progressed at the time of diagnosis [KAA2016] .

However, this is only possible if the treatment intensity (number of chemotherapy cycles, radiation therapy) - within the scope of the various therapy groups - is specifically tailored to the patient's illness. Patients with more advanced disease (therapy groups II and III) require more intensive therapy than patients with early disease stages (therapy group I) so that they have a comparably good prognosis.

Prognosis in patients with recurrence of Hodgkin lymphoma

According to the Hodgkin's Disease Study Center (Halle), around 11% of children and adolescents with Hodgkin lymphoma experience a relapse or progression of the disease despite treatment (tumor progression).

As a rule, good long-term treatment results and cures can still be achieved in the event of a relapse. The prognosis for the individual patient depends primarily on the point in time at which the relapse occurs and how intensive the treatment was at the time of the initial illness.

Patients who relapse late (that is, later than 1 year after the end of therapy) have a very good chance of recovery with combined chemotherapy and radiation therapy (10-year survival rates of over 90%) [SCH2005l]. Patients whose disease was at an early stage at the time of the initial diagnosis (patients in therapy group 1) and / or who have not yet received any radiation therapy during the initial treatment also have a good prognosis.

Patients with an early relapse (recurrence between three and twelve months after the end of therapy) and patients whose disease does not respond to the initial treatment or even progresses (10-year survival rates of around 75 and 50%, respectively) have less favorable chances of recovery with conventional chemotherapy and radiation therapy. ) [SCH2005l].

The same applies to patients who received very intensive chemotherapy and radiation therapy as part of their initial treatment due to their advanced stage of the disease. In these patients, due to the high risk of relapse, there is often only a good chance of a cure if a particularly intensive form of therapy, high-dose chemotherapy with subsequent stem cell transplantation, is carried out.

Data source German Childhood Cancer Registry

The numbers apply to children and adolescents up to the age of completed
14 years of age (period 2006-2015, unless otherwise stated) .more