Scientists have discovered that children of women during pregnancy in Calais have discovered bacteria of the species Prevotella corpi, were less prone to allergies. Eating large quantities of fat and fibre during pregnancy has also been associated with a reduced risk of Allergy development in children. Article published in the journal Nature Communications.
The spread of allergies is explained by the hypothesis of the influence of hygiene, which in 1989 pushed the British scientist David Strachan (David Strachan). The hypothesis is that the hygiene reduces the load on the immune system of the organism of children, and the immune system begins to work against safe substances.
This effect may be mediated by changes in the human microbiome: when we care about sanitation, we get not only less harmful but also beneficial bacteria. There is an assumptionthat loss of species of bacteria that lived in the bowels of our ancestors, leads to the spread of chronic diseases. It is also known that the gut microbiome of pregnant women having influence on development of the immune system of the fetus, and immunological composition of umbilical cord blood is associated with risk of allergies.
Bacteria of the genus Prevotella, which are part of the normal microbiome of the intestine, is much less abundant the inhabitants of westernized countries than traditional pre-industrial societies. These bacteria break down fiber and excrete short-chain fatty acids and other metabolites. These substances can cause inflammatory response and affect the development of immunity, and also to penetrate through the placenta and to change the immune response of the fetus.
A group of scientists from Australia and USA under the leadership of Peter Willemina (Peter Vuillermin) analyzed the fecal 362 pregnant women. Their children at the age of one year carried out an Allergy test, and during the first year of life three times taking tests. In stool samples were determined by the composition of the microbiome. In addition, women filled out a questionnaire about your diet: bacteria Prevotella eat fats and fiber, and the content of these substances in food could be due to the composition of the microbiome.
In 58 of 362 children to year developed a food Allergy. It turned out that the presence in the intestinal microbiome of pregnant women the bacterium P. corpi correlated with the absence of food Allergy in their children (p < 0.001). The children of women whose Kale was increased content of P. corpi, also had more of these bacteria. The structure of the rest of the microbiome was not associated with Allergy in children.
With the development of food Allergy also did not correlate the content of short fatty acids in the feces, but this is probably due to the fact that the bacteria of the intestine to actively absorb these chemicals, and in the excrement of their remains. Children whose mothers during pregnancy consumed more fat and fiber were less prone to allergies, and this relationship was intensified when mothers in the intestines dwelt P. corpi. And those who took antibiotics during pregnancy (in total there were 11 people) generally have not found P. corpi.