Dopamine does in the brain is not
only the role of the neurotransmitter, but may also chemically modify associated with
Proteins and DNA thereby affecting gene expression. In particular, this process
occurs when the formation of dependence on cocaine. As demonstrated
the authors of the article in Science,
blocking diaminopropane reduces interest in cocaine dependent
drug rats after a period of abstinence.
Dopamine is the Central neurotransmitter in the system
reward in the brain, which allows you to get pleasure from
a variety of incentives and is directly involved in the formation of drug
dependencies. So, the main addictive result of cocaine use
is the release of dopamine in a brain area called the ventral region
tires, and activation of “downstream” areas of the brain associated with reward, such
also, the nucleus accumbens.
The formation of dependence is accompanied by a change
gene expression in neurons of the midbrain and in the dopamine-mediated error
(dopamine-producing) neurons. The change in the level of transcription including
depends on the changes in the number and type of chemical modifications of histones —
proteins associated with DNA.
In previous studies the employees of the Department of neuroscience Medical school at mount Sinai in new York under the leadership of Jan Meza (Ian Maze) showed that
the neurotransmitter serotonin is capable to chemically modify histones on the balance
glutamine. In his new work, scientists have discovered that chemical modification of
dopamine on the balance of glutamine also occurs in neurons and this process
leads to a change in gene transcription in neurons in the dopamine-mediated error. In addition,
change diaminopropane histone H3 in neurons of the ventral region of the tire associated with
the use of cocaine.