Female gender protected mice from peritonitis

The scientists found different activity level peritoneal macrophages in serous membrane of the abdominal cavity in mice of different sex and age. The authors of an article published in Science in Immunology, also reported that gender regulates the influence of local homeostasis on gene expression in peritoneal macrophages, which are responsible for the protection of the serous membrane of the abdominal cavity from infection. So, female mice showed increased resistance to peritonitis caused by Streptococcus pneumoniae.

The distinction of male and female organisms, sexual dimorphism is manifested not only in visible to the naked eye the anatomy of the male and female. Hormonal and biochemical profile, levels of expression of different genes — all of this also distinguishes one gender from another. Another important characteristic of flooring is and the body’s susceptibility to some diseases due to the difference of the immune response in men and women. Therefore, sexual dimorphism, especially in the context of the treatment of various diseases, are now studying more often.

Scientists under the leadership of Calum Bain (Calum C. Bain) from the University of Edinburgh in his study focused on macrophages receptors CD102 and CD209b with high levels of expression of antigen F4/80 marker of macrophage cells. In my previous research they have found that, in contrast to the resident macrophages in other tissues, the number of peritoneal macrophages CD102 coming from the bone marrow, is strongly dependent on sex: they were more in males, but not female mice.

First, scientists investigated the effect of gender on the replenishment of the pool of peritoneal macrophages depending on the age of the mice. In prepubertal period (four weeks age) the degree of labeling of peritoneal macrophages CD102 yellow fluorescent protein was relatively similar among male and females with a slight predominance in females. To shestnadtsatiletnego age the number of macrophages CD102 increased both in males and female mice compared to their four-week performance, however, higher levels of labeling were detected in peritoneal macrophages of males (P < 0.0001). Thus, gender affects the differentiation of peritoneal macrophages is not in the bone marrow (i.e. not on the level of high Potentate cells), and the serous cavities (p < 0.01), and this influence can be detected only after puberty.

It was not observed difference (P < 0.0001) in the CD102 number of macrophages in the pleural cavity, where both male and female macrophages showed high levels of marking. These data confirm that the peritoneal environment controls the distribution of macrophages and that sexual dimorphism of these macrophages occurs after puberty.

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