Genetic markers allowed to blame TV viewing in the development of cardiac ischemia

Genome wide Association held for more than
400 of thousands of Britons over 40 years has allowed us to discover genetic markers for the tendency
spending time in front of the TV. As reported by the authors of the article in Nature Communications,
watching TV (but not sitting) was associated with the development
coronary heart disease in this age group.

A sedentary lifestyle is a risk factor for development of cardiovascular
diseases. However, scientists from the University of Groningen (the Netherlands) on
example sample of British residents from the database UK Biobank is suggested that don’t
all habits are equally harmful for health. For 422218 participants of the European
origin aged 40 to 69 years, they analyzed the relationship between risk
of coronary heart disease (CHD) and leisure
time watching TV or computer use (obviously not for
prolonged viewing of TV shows, but for something else). About their habits people
wrote in questionnaires at inclusion in the database. On average, the participants spent
near the TV 2.8 hours a day, and at the computer hour a day.

Over 6 years of observation from the moment of inclusion in the database of coronary
heart disease occurred in 12555 people from the sample. It turned out that the tendency
spending time watching television is positively correlated with
the probability of developing CHD, even after controlling for other risk factors, such as
Smoking and increased body mass index. To use the computer like this
correlation was not found. For such a “sedentary” activities like driving,
positive correlation with CHD was found. But scientists have shown that there
correlation of spending free time with education — less educated
people on average gave preference to television, and more educated —
computer.

In addition, genetics has conducted genome-wide Association analysis
for 408815 man that had available data about single nucleotide
the polymorphisms in their genomes. For the inclination to spend time in front of TV
found 145 genetic markers, and to use the computer 36
markers. Most of the associations related to the development of the nervous system and
vital functions of nerve cells. Although found 15 markers were common
for both classes, at the genetic level the relationship between preference for TV
and computer scientists have not identified.

After the identification of markers for these lessons, as well as
using the known genetic loci for predisposition to coronary artery disease, the authors
article conducted a Mendelian randomization is a method of statistical analysis
allowing to establish a causal relationship between two events, and
estimate that the tendency to watch a lot of TV is a factor
risk of coronary heart disease, and not Vice versa.

Commenting on the choice of activities, the researchers said that
TV viewing is associated with the most prolonged and passive pastime
with a small number of breaks, which also often accompanied by
by snacking. Previously it was shown that watching TV is a popular
occupation is in the specified age group. In addition to damage to the heart,
TV blamed in the decline of cognitive abilities.

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