GM mice with thermoreceptors in the eyes of the acquired infrared vision

Swiss scientists have proposed to treat disorders of vision in
help extend its capabilities to the infrared range. To check
the concept in the retina of blind mice was expressed genetically modified thermoreceptors
which activated the laser. According to the authors of the article in Science, immediately after
flashes laser mouse was able to distinguish the object in front of you.

Cause of vision loss in the elderly is often
degeneration of photoreceptors in the retina. Light-sensitive cells
mammals perceive visible light with wavelengths in the range of 390-700
nanometers.

Researchers from the Institute of molecular and clinical ophthalmology
Basel under the direction of Daniel Hilera (Daniel Hillier) and Boughton Roski (Botond Roska) has proposed an unusual solution to recover
the ability of orientation in space to complement the light-sensitive proteins
cells of the retina sensitive channels that would
to perceive infrared radiation with a wavelength of about 900 nanometers.

In nature this ability is at some snakes, though
infrared radiation with a wavelength from 1 µm they perceive not with the eyes but
with the help of special on. Visual and thermal information are combined in
the brain of the snake and allow it to perceive the environment with higher resolution,
than just by seeing it. Thus for the perception of temperature they meet
ion channels of the TRP family
(transient receptor potential),
which begin to conduct current when heated. Theoretically, these proteins can
to Express in retinal cells, but their activation is required too
powerful radiation that can damage tissues.

To increase the sensitivity of TRP channels, bioengineers
sewed them amino acid sequence that is recognized by specific
antibody. The antibody, in turn, attached gold nanoparticles,
which would enhance the emission through surface plasmon resonance. Received
the system would activate the channels by light with less energy and
to protect the retina from damage.

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