Human stem cells restored myelin sheath in the brain of adult mice

Cells predshestvenniki glia, which demielinizirutaya transplanted into the brain of adult mice, spread across the front of the brain, differentiate into oligodendrocytes and restore myelin sheath of axons. As a result, the animals had improved motor function and electrophysiological parameters of nerve fibers. Article published in the journal Cell Reports.

Violation of the myelin sheaths of neurons leads to a number of neurodegenerative diseases, including multiple sclerosis, and makes a contribution to some mental disorders. Scientists propose to compensate for demyelination by transplantation of glial precursors of oligodendrocytes, which form myelin sheath in the Central nervous system.

Already successfully transplanted human oligodendrocyte precursors of newborn mice with mutations in the gene for myelin basic protein (OBM). These animals have impaired formation of myelin sheaths, shortly after the birth develops a tremor (shaking), and the animals die at the age of several months. Transplantation of oligodendrocyte myelination was restored and extended the life of mice. However, scientists are still not investigated whether the precursors of glial cells to settle in the adult brain and marineservice it.

A group of researchers from Medical center of Rochester University led by Steven Goldman (Steven Goldman) transplanted precursors of glial cells to adult mice with mutations in the gene for the WSO, and also for animals that have artificially caused demyelination with cuprizone. Injection of stem cells was done in the corpus callosum of mice at the age of four to six weeks (eight “quivering” mice and 14 control). After 12-15 weeks after surgery, the brain was removed and evaluated the distribution of donor cells, the differentiation of oligodendrocytes and myelination of neurons.

Transplanted glial precursors were successfully settled around the front brain of mice, and stimulated the formation of myelin sheaths. These cells have expressed genes associated with differentiation into oligodendrocytes, the movement of cells and the beginning of myelination.

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