American scientists have grown a piece of human skin in vitro from scratch from embryonic
cells. In the resulting organoids formed not only the basic layers of the skin
the dermis and epidermis, but hair follicles, which after transplantation of a piece
mouse skin grew hair. The work published in Nature.
Skin is a complex multilayered organ, which is in the process
embryogenesis consists of different germ layer. The surface of the skin, or
the epithelium originates from the ectoderm (from which is also formed of a nervous
system), and deep layers of the skin (the dermis) that contains blood vessels, glands and
hair follicles — mesodermal origin. Complex structure and mixed
origin makes it difficult to grow skin in vitro.
Lab-grown leather could be useful not only to scientists,
exploring its functioning, but also patients suffering from burns,
baldness and a number of more serious diseases. For example, we talkedabout
epidermolysis bullosa, where the skin literally separating from
the underlying structures. This disease is genetically determined, but the problem can be solved
transplant lab-grown healthy epithelium. In this case scientists
managed to restore the skin sick boy with the help of genetic
modification and cultivation of its own epithelial cells.
In the new work, researchers from Children’s medical center
Boston, Harvard Medical school and Indiana University under the direction of Karl Keller (Karl Koehler) was able to grow in
a Petri dish is not just the epithelium, and a full layered skin glands
nerve endings and hair follicles. The basis for organoid (organ miniature) become pluripotent human stem cells that
incubated with a complex cocktail of growth factors within a few months.