Lactobacilli of the intestine tied with a good memory of mice

Mouse in the intestine which was a lot of bacteria four families, better remembered threat compartment in the test passive avoidance. In animals administered lactobacilli or pure lactate, the memory was better than the control mice. The proportion of cells expressing the neurotransmitter gamma-aminobutyric acid in the hippocampus of these animals was increased. A study published in the journal Microbiome, opens up the prospect for a new approach to the treatment of memory disorders.

The microbiome of the gut have not only General health, but also with behavior and memory. In mice it was shown that probiotics with lactobacilli and bifidobacteria reduce anxiety and improve the memory of animals. How gut bacteria affect brain processes is not clear. It is only known that the ingestion of lactobacilli increases the quantity of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and receptors to his brain.

Scientists from Luxembourg and the United States under the leadership of Antoine Snyders (Antoine Snijders) of the National laboratory behalf of the Lawrence Berkeley studied the memory of mice of different lines of the project “Collaborative Cross”. The genetic diversity of these animals is much higher than conventional laboratory lines — this allows you to find new genes that are associated with different processes in the body.

535 29 mice were trained for passive avoidance: in one of the two compartments of the experimental chamber the animals were electrocuted, and three days later checked, what branch they will prefer. The better the memory of mice on the event, the more time passed before the mouse came into the compartment where they were electrocuted.

The memory of mice significantly varied between the lines, and scientists have identified 222 gene, variations in which were correlated with memory. About a third of these genes are already known that they are associated with the memory; the expression of 65 found in the brain. So, found 65 new genes that might participate in memory processes.

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