Memory consolidation during sleep demanded neurogenesis of the hippocampus

The neurons of the dentate gyrus of the hippocampus, which appear as a result of neurogenesis in adult mice, are involved in consolidation of contextual memory during REM sleep. Most of the young nerve cells were excited during sleep, was active and in previous training. The suppression or activation of new neurons during REM sleep has violated the consolidation of memory and the work of immediate early genes in cells of the dentate gyrus, and in the young neurons of the elongated spines. A study published in the journal Neuron.

Dentate gyrus of the hippocampus is one of two areas in which discovered adult neurogenesis, but the function of young neurons in the it while is poorly understood: partly due to the fact that such cells a little, and partly due to the fact that they opened recently. It is clear that young neurons play an important role in memory formation — he hippocampus is a key structure for long-term episodic memory, and new neurons are particularly plastic, which is handy for creating memorable tracks.

To prove the participation of young nerve cells in memory processes, in several works they were inhibited using the methods of optogenetics during learning or memory retrieval. In one experiment, the activity of young neurons tried to demote and promote. Interestingly, all these manipulations resulted in a violation of memory means for memorizing important fine tuning of new nerve cells.

Scientists from the UK, USA and Japan under the guidance of Masanori Sakaguchi (Sakaguchi Masanori) from the University of Tsukuba by using calcium imaging recorded the activity of young neurons in mice during learning and after memory consolidation during sleep. They have created a line of mice in young (less than four weeks) neurons which expressed the calcium biosensor. When you activate the cell in its cytoplasm consisted of calcium, and the sensor started to fluoresce. Glow in the hippocampus has caught microendoscope microscope, which is mounted on the head of the mouse and allows it to move freely.

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