Patch artificial cells restored heart after a heart attack

Scientists have created a patch for the recovery of the heart after myocardial infarction. In the cellular matrix of the myocardium of a pig placed artificial stromal cells of the heart, which contained paracrine factors in living human cells. Trim helped to restore tissue and improve heart function after induced myocardial infarction in rats and pigs did not cause rejection and was not toxic. Even after freezing for a month the patch has not lost its properties. A study published in the journal Science Translational Medicine.

Coronary heart disease is one of the main causes of death worldwide. After the disease is irreversible changes, for example, when developing myocardial infarction is necrosis (death) of a portion of the heart. After a heart attack begins the process of reparations, which often leads to arrhythmias and heart failure. To influence this process and to start the regeneration of cardiac tissue, scientists are trying with the help of cell therapy: stromal cells of the heart, for example, secrete paracrine factors that act upon the damaged cardiomyocytes.

However, living cells are very vulnerable, before transplantation, they need to contain special conditions to preserve viability, therefore, cell therapy is time-consuming and expensive. The transplanted cells are easily washed out due to active contractions of the heart, and the number of rooted cells are usually small. What is left, may attack the immune system, if not autologous transplantation. In addition, the mechanism of action of cell therapy are not completely clear, and undifferentiated cells uncontrollably divide and become a tumor.

Ke Huang (Huang Ke) from the University of North Carolina and his colleagues have created a patch with a synthetic stromal cells of the heart. To make artificial cells from the stroma of the human heart singled out the secret and put it in biodegradable microparticles of polylactic-co-glycolic acid. These capsules with a vacuum filter implemented in a matrix of the acellular matrix of the myocardium of the pig. The advantage to this model is that cell-free patch easy to store (can be frozen) and it does not cause rejection.

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