Patches of cyanobacteria healed chronic wounds in diabetes

Scientists from China have created a patch with the cyanobacteria, which provide the wound with oxygen and helps her heal. The patch was developed for chronic wounds that arise from diabetes. With the patch the rate of wound healing in mice with diabetes was the same as in normal animals; trim helped to settle down the skin graft. Article published in the journal Science Advances.

A quarter of patients with diabetes is the risk of development of chronic wounds, including diabetic foot purulent-necrotic and ulcerative skin lesions, which in advanced cases lead to amputation. Constantly high blood glucose in the blood leads to hypoxia (lack of oxygen) in the tissues resulting in wounds can start the growth of blood vessels and the healing process.

To increase the flow of oxygen to the tissues of patients with diabetes, try using oxygen therapy: patients are placed in hyperbaric chambers where they breathe oxygen at high pressure, or oxygen gas serves locally in the wound area. However, these treatments increase the oxygen level of only one to two hours until the patient is in the chamber. As a result, the treatment of gaseous oxygen effective only in individual cases; we must look for ways to deliver to the wounds of dissolved oxygen.

Scientists from Nanjing University under the guidance of Jinhui From (Jinhui Wu) decided to use local enrichment dissolved oxygen cyanobacteria Synechococcus elongatus. These single-celled creatures capable of photosynthesis and produce oxygen from inorganic carbon compounds (carbon dioxide and carbonates). Cyanobacteria were placed in hydrogel beads with a diameter of one millimeter of the skin. Attached to the skin of the patch coated membrane of Teflon with holes in the 0.22 micrometer through their skin and the patch can exchange gases and liquids.

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