Physically active pregnant mice stocked brown fat themselves and their children

Scientists from the University of Washington suggested that
the prevalence of obesity in the modern Western world can influence
sedentary pregnant women. In experiments on mice
researchers have shown that physical activity during gestation of the offspring
leads to an increase in the number of brown fat not only have themselves
pregnant females, but their offspring. Accumulated during fetal development
brown fat has helped to reduce the effects of high-calorie diets in mice, the authors
article in Science Advances.

In contrast to conventional white fat, the function of which is
in spasenii energy, brown fat necessary for the body’s thermoregulation. Cells
brown fat actively break down lipids and convert energy into heat due to special
mitochondrial protein Ucp1 (actually,
due to the large number of mitochondria this adipose tissue and becomes brown).
Brown fat in the body many animals hibernate and have babies.

Previously it was believed that in adults it is almost there, but
recent years researchers have found that ordinary white fat adipocytes can
to turn into brown. Adipose tissue with some brown adipocytes called
beige, and its share, apparently can be raised and in adults in
particular, with the help of exercise. Physical activity leads to
the release of tissue hormones, which lead to the transformation of adipocytes from white
in brown. The transformation of white fat to brown is seen as a means of combating obesity.

Researchers from the laboratory of the biology of the growth of the University of Washington under the leadership of Min Do (Min Du) found this effect in pregnant women
mice. The researchers divided a group of pregnant females on two (5-6 mice), and one
of classes every day made for an hour run in the simulator. Besides being physically
the active mice gained less weight during pregnancy than females, leading
a sedentary lifestyle, they also increased the ratio of brown fat to weight
body at almost 40 percent, and the percentage of white fat decreased. In addition,
exercising mice had lower glucose in the blood, and higher sensitivity
tissues to insulin.

In addition to the immediate effects of exercise on female scientists
found similar effects for seed mass and percentage body fat in white
was lower than in the control group, but the percentage of brown fat is higher. After
the eight-week diet with a high fat diet was that daughter
exercising mice gained less weight than the daughters of sedentary mice, even though
eat more. For males no such difference was found. Metabolic
indicators such as glucose tolerance and insulin levels, also
was better in the first group.

Leave a Reply

Your email address will not be published.