Protein herpesvirus associated with the development of depression

Japanese scientists have shown that infection with the herpes virus
the sixth type may be associated with the development of major depressive
disorder. However, for the development of the disease important viral protein that
synthesized only in a certain type of nervous tissue cells. The presence of antibodies
this protein may serve as a risk marker for the development of depression, as
demonstrated by the authors of articles published in an open access journal
iScience.

The family of herpes viruses is very extensive, and includes
eight different types that can cause infections in humans. In addition
herpes simplex virus (culprit “cold” on the lips), there will be
oncogenic pathogen Kaposi’s sarcoma, and cytomegalovirus and the virus
Epstein — Barr (about it we recently told in detail in a material “the Quiet
pandemic”).

Characteristic of this group of viruses — ability for a long time
to remain in a latent phase of the infection, does not prove itself. Including
this is why many people become asymptomatic carriers of one or
several herpes viruses. The impetus for the aggravation of the infection and the development of the disease
can be a stressful situation and a serious weakening of the immune system in
the result of HIV infection or medication after the transplant
bodies.

The list of diseases that can cause infection
the herpes viruses (HHV), in recent time include and breakdown. To
example, nervous tissue associated virus type 6A and
6B. The latter usually causes pseudorange in children, however, the posthumous
brain studies of people who in life suffered from a major depressive or
bipolar disorder, showedthat the disease can be due to the presence
viral DNA HHV-6B and virus-induced inflammation in certain parts of the brain.

According to the researchers from University medical
school Dzhikey under the leadership of Kazuhiro Condo (Kazuhiro Kondo), initially the virus HHV-6B enters the respiratory (herpes viruses
transmitted including airborne droplets), and from there penetrates
astrocytes (a type of immune cells) of the olfactory bulbsdirectly
associated with the brain. In bulbs the virus usually is delayed in entering
latent phase of infection.

Scientists have identified one protein is the latent phase (SITH-1), the synthesis of which
was associated with astrocytes, and it was expressed in the olfactory
the follicles of mice. It turned out that the experimental animals decreased
follicles, and in the test suspension by the tail, they often remained motionless,
indicating signs of depression. While antidepressants reduced
depressive symptoms in this group of mice.

Analysis of brain tissues of experimental animals showed that
they had a reduced level of neurogenesis in the hippocampus and increased levels of hormones
the hypothalamic-pituitary axis, in particular, kortikoliberina. Long
the effects of this hormone on the Central nervous system leads to the development of
chronic anxiety, sleep disorder and appetite. Apparently, the relationship
virus and depression in mice is the destruction of the olfactory bulbs and
indirect activation of the hypothalamic-pituitary axis, the researchers concluded.
Signs of inflammation in the nervous tissue they found.

In cells the viral protein SITH-1 protein interacts with CAML, triggering intracellular calcium current,
what will trigger a program of cell suicide. To confirm
the hypothesis of when SITH-1
and depression on people, the researchers checked for the presence of antibodies to a complex of SITH-1-CAML in a group
patients with diagnosed major depressive disorder (84 people)
and in the control group of people without psychiatric diagnoses (82).

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