Saturated fats and endotoxins worsened women

American scientists experimentally showed that the consumption of foods rich in saturated fats, can disrupt cognitive function. Participants of their experiment, worse coped with the test for attention after we ate lunch, made with palm oil, rich in saturated fats, than if their lunch cooked in sunflower oil (unsaturated fats). The food, however, had no effect on the care women, if their blood was initially high concentration of endotoxin: in this case, participants coped with the test equally bad no matter what they were fed, write the scientists in The American Journal of Clinical Nutrition.

Nutrition affects not only physical health, but brain health and cognitive function. For example, experiments on mice showthat the excess carbohydrate and fat can impair learning, as well as the deterioration of cognitive functions due to excess of fat in the diet indicate and population studies.

However, many studies in assessing the impact of macronutrients on cognitive functions do not take into account, for example, which group consumed fats (e.g. saturated and unsaturated). In addition, the estimated consumption of fatty foods on cognitive abilities is still in need of more empirical data. Get them decided scientists led by Annelise Madison (Annelise Madison) Medical school the Ohio state University. In their experiment involved 51 women (mean age 53 years) without chronic diseases (particularly cardiovascular) and metabolic disorders. While 32 women from the sample experienced breast cancer is, however, taken into account in the data analysis (and, according to scientists, the results are not affected).

To reduce the variability of the data, the day before the start of the experiment, participants ate the same, and 12 hours before the procedure they were asked to refrain from eating at all. Participants randomly divided into two groups and gave the same Breakfast: scrambled eggs, sausages, the Turkey, rolls and gravy. The calorie content of meals and total fat content were similar between groups, but differ in the number of saturated and unsaturated fats: in the preparation of used palm oil (containing saturated palmitic acid) and sunflower (contains unsaturated oleic acid). Within one to four weeks, the experiment was repeated, changing the participating places: thus, all tried both dish.

Hour before meals the scientists collected blood samples from participants to measure of concentration in their body markers of endotoxemia — falling endotoxins lipopolysaccharides in the blood from the digestive system, which leads to the development of inflammation: soluble CD14 protein, lipopolysaccharide-binding protein (LBP) and their relationships.

Immediately after lunch the participants were given a cognitive test for attention: they are needed as quickly as possible to press the key when on the screen appeared a certain figure — and ignore the rest. It turned out that after meals with plenty of saturated fat women are worse than said desired shape (p = 0.02), indicating a decrease in attention. Also the test results were lower in women with high concentrations of LBP (p = 0.04). Those participants whose blood concentrations of LSB, and the ratio of the concentration of LBP to CD14 was higher also gave more incorrect answers, they could not concentrate and did not have time to perform the task, if the rate of appearance of stimuli was increased.

In addition, it was found that in women with endotoxemia the indicators of attention weakly depends on what dish they ate — their answers were in General worse (p < 0.05). Scientists thus showed that the consumption of saturated fats and work of endotoxins in the body can separately affect cognitive function. It also means that initially high concentrations of endotoxins in the blood can neutralize the positive effect from replacement of saturated fat for unsaturated.

However, for normal cognitive function (especially in the elderly) may be more important is not the products themselves, and their combination in diet: for example, recently, scientists foundthat people diagnosed with dementia, less variety in their diet, as well as, for example, prefer to combine red meat with bread and potatoes rather than fresh vegetables, as do their healthy peers.

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