By combining phylogenetic analysis of the genomes of SARS-CoV-2 with data on trips of scientists have reconstructed the early stages of the outbreak COVID-19 in our country. Ancestors studied 211 isolates came to us in late February — early March 2020 66 result of transfers from Europe and one transfer from China. This is about one transfer for three of the viral genome, and the researchers suggest that the true number of transfers was much higher and the score will rise if you increase the sample. They subsequently gave rise to local viral lines, the biggest line belongs to the largest in Saint-Petersburg flash COVID-19 in the Center of Vreden. Preprint posted on the website medrxiv.org
Thanks to the combined efforts of scientists from all over the world in the GISAID database is the main repository of viral genomes of SARS-CoV-2 — half a year has accumulated approximately 66 thousand sequences. This is an unprecedented amount of data of this kind in the history of science, which can be traced the spread of the virus across the planet and its evolution. Despite the fact that is in the top five countries by the number of cases COVID-19, local viral genomes are grossly underrepresented in the database — to date there are only 253 (this is 14 less than in the whole of Finland). However, the combined analysis of local and foreign genomes and data about flights allows you to partially trace the development of the epidemic in our country.
A group of researchers from Moscow and St. Petersburg under the leadership of George Bazykin (Georgii Bazykin) conducted an analysis of the 211 viral genomes, collected in the early stages of the outbreak, from 11 to 23 April. 135 samples sequenced at the Institute Smorodintseva, and 76 took from GISAID database. The resulting dataset well reflect the picture of the epidemic, the centers of which in the country was initially in Moscow and St. Petersburg.