Scientists have created water-soluble silicon nano-needles patch containing anti-cancer agent. The film of polyvinyl alcohol for minutes, dissolved under the action of the sodium phosphate buffer solution, leaving the body of the subjects of the mice of silicon an array of nanoneedles that release specified portions of chemotherapeutic agents doxorubicin when dissolved in the tissues. The results of a study published in the journal ACS Nano.
The main cause of melanoma is ultraviolet radiation from both the Sun and from artificial sources of light (e.g., tanning). Often cancer treatment requires repeated chemotherapy, which increases the risk of poisoning by toxic drugs and occurrence of side effects. The recently proposed nanoscale needles of porous silicon can provide the interstitial entry of medicines minimally invasive method and a controlled supply of medication due to the projected destruction of the threads when interacting with tissue fluids. The silica and the hydrolysis products have proved their safety. However, flexible polymer patches nanowires can bring discomfort to the patient due to the deformations of tissues during movement, so it is important to thoroughly test this method.
Hyung Jun Kim (Kim Hyungjun) with colleagues from Purdue University have created and tested on rodents plaster of soluble in the salt water of polymer with nano-needles of porous silicon, which contain drug molecules. For this, they have grown silicon needles, separated them from the plate and attached them to thin film of polyvinyl alcohol size of one square centimeter. For the formation of covalent bonds between the silicon needles with the chemotherapy medication doxorubicin, used 3-triethoxysilylpropyl succinic anhydride as cross-linker, linking drug molecules to the surface of the silicon needles. To track the dissolution of filaments in cells, the researchers attached fluorescent label.