“The gene of long life” does not help the better flies to climb the walls

American gerontologists have checked one hundred and fifty lines of Drosophila respond to calorie restriction. It is believed that this procedure prolongs life, but not all flies do are living longer. In addition, the long life they have not always been matched by improvements in health and physical stamina. Scientists have discovered that the effect of diet on length of life and health are two separate mechanisms that are determined by different genes. One of these genes was named in honor of the sculptor Daedalus, and the second in honor of Decima, the Roman goddess of fate. A study published in the journal Current Biology.

The most reliable of the known ways to prolong life (at least in animals), which allows to do without the meds, is food restrictions. Different methods prescribe to reduce your calorie intake or eat less of certain substances (in different diets it can be proteins or carbohydrates).

However, not all experiments with diets could prolong the life of experimental organisms. You can, of course, is to be attributed to the differences in the methods. But it is possible that the explanation lies in the genes: each laboratory works with its line of animals that are related to each other, but may be not much similar to individuals of the same species from neighboring laboratories. And if the do genotype determines the response to dietary restriction, then, and not for all people they can be effective.

Kenneth Wilson (Kenneth Wilson) at the California Institute of aging research named Tank and his colleagues used a collection of 161 lines of fruit flies to figure out how each of them reacts to calorie restriction. Scientists were interested in two aspects of life flies: the duration of life, on the one hand, and physical activity on the other. The fact that it is still unclear, the same or different mechanisms are provided with a long life and healthy life. And it may be that calorie restriction prolongs existence, but does not add health (we already talked about this research on the lemurs), or, on the contrary, makes the body more active, but reduces the days.

For a start, the researchers measured the lifespan of 161 lines of flies in terms of nutrition (ad libitum) and calorie restriction. It turned out that the diet affects different animals according to their genotype in different lines under its action the duration of life varied from -65 to +1250 percent. Nevertheless, the authors followed a pattern: the longer the line lived alone, without interference, the weaker she acted the calorie restriction. Among the long-lived lines diet proved helpful less than 46%, and for short-lived — a whole 82 percent.

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