Scientists from St. Petersburg Institute of influenza, name Smorodintseva for the first time sequenced the genome of then variant of the coronavirus SARS-CoV-2, and found that it generally differs little from the original Chinese versions, but genetically closest to European viruses. About N+1 was announced by the head of the research group Andrey Komissarov.
The coronavirus, which has led to a pandemic of diseases COVID-19, received the name of SARS-CoV-2. A new virus similar to the causative agent of SARS, SARS-CoV that caused the epidemic in 2003, while he, like other viruses, continuously evolyutsioniruet. During the time elapsed since the beginning of the outbreak, a few dozen genetic variants (see the family tree of the virus on the website of GISAID), although these variants do not differ too much from each other.
Few days ago Institute of influenza, declaredthat scientists have obtained the first complete genome of a coronavirus SARS-CoV-2 from samples taken from the patient from. According to Andrey Komissarov, RNA virus was isolated on 15 March in Saint-Petersburg from a nasopharyngeal swab at thirty women. Several more days were required to recheck and “rebuild” of the genome. This has assisted colleagues in the Center for bioinformatics and algorithmic biotechnology, St. Petersburg state University.
“We found five nonsynonymous substitutions in the genome compared to the Chinese version, it’s quite a bit,” said the Commissioners. In his opinion, it is unlikely that the found differences can seriously change the virus so it required to change approaches to vaccine development. Scientists intend to create an consortium for the sequencing of the virus SARS-CoV-2 and invite them to participate with other scientific organizations working in the field of NGS.
In turn, member of the Institute of information transmission problems, Georgii Bazykin, together with colleagues analyzed the peculiarities of then strain.
On their genetic characteristics, says he, then virus “is inside a large predominantly European clade, with a large number basal of the European sequence”. His words were confirmed by the Commissioners: “Yes, he is grouped with the European sequences Clyde G”.
“The predominance of the basal European sequences in the neighborhood with our strong testimony in favor of the importation to from Europe. This treasure, the base of which hit the St. Petersburg sequence, is quite interesting: it is possible to get sequence from a known “second” outbreaks of closely related strains from Washington state. It seems that the group is close to the European strains have spread in several very different directions (super-spreading event at the airport?) Really need more sequenced strains to know the details; the emergence of additional data, the picture will be refined,” — says Bazykin.
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